找色妹妹 副长处 副系主任 王韵训导
找色妹妹
王韵,北京大学博雅特聘训导、北京大学麦戈文脑盘算院PI,博士生导师,国度隆起后生基金获取者,训导部长江特聘训导。现任北京大学临床医学高级盘算院副院长,神经科学盘算所副长处。
社会兼职:现任中国生理学会理事长、亚大生理科学纠合会(Federation of the Asian and Oceanian Physiological Societies, FAOPS)第一副主席、训导部高级学校基础医学类教学教导委员会副主任委员、海外神经肽协会中国分会布告长和中国神经科学学会常务理事。
科研标的:
课题组主要从事神经系统细胞信号转导的盘算。概括行使多学科技能,整合分子生物学、生去世学、遗传学、电生理学、形态学和作为学等技艺,主要进行以下两方面的职责:
1.痛与痛觉调制的细胞信号转导通路:采纳慢性病感性凄冷模子,盘算痛觉传导通路中,外周和核心神经元发生的可塑性变化,并围绕细胞信号转导的核心分子——卵白激酶,潜入探讨慢性痛,联系痛联系负性心境及痛顾忌产生的特异的信号通路,以期发现新的镇痛靶点或镇痛药物,为经管临床镇痛问题提供新想路。
2.神经发育和挫伤开拓及脑要紧疾病机制:采纳体外培养细胞和在体动物模子,探讨参与神经元极性设置、迁徙、树突发育、突触变成和修剪等神经发育经过,以及外周神经挫伤后开拓(与发育经过享有一些共同的分子机制)和神经元缺血挫伤/抗挫伤经过的关节分子,旨在推崇先天性神经发育疾病,神经退行性疾病及后天性神经挫伤如机械、缺血挫伤等经过的病理机制,找到其中的关节分子,联想可能的打扰政策,从而为一些临床常见神经精神疾病的调理冷漠新技艺。
训导阅历:
1. 1984.9~1989.6,江西医学院医疗系临床专科,于1989.6获医学学士学位
2. 1989.9~1992.6,北京医科大学生理系,于1992.6获医学硕士学位
3. 1993.9~1996.6,北京医科大学生理系,于1996.6获医学博士学位
职责阅历:
1. 1992.08~1993.09,北京医科大学生理系消化盘算室,助教
2. 1993.09~1998.12,北京医科大学生理系神经科学盘算中心,讲师
3. 1999.01~2004.08,北京大学神经科学盘算所,讲师,副训导
4. 2004.08~于今,北京大学神经科学盘算所,训导
5. 2000.12~2002.12,好意思国国立卫生盘算院(NIH),拜谒学者
在研科研技俩:
1. 科技转变2030—“脑科学与类脑盘算”要紧技俩:生理病理情状下痛觉-心境交互作用的调控机制及打扰政策(2021ZD0203200),3500万,2021.11-2026.11,在研,技俩认真东说念主。
2. 国度当然科学基金重心技俩:触诱发痛神经环路机制盘算(32030052),298万元,2021.1-2025.12,在研,主捏。
曾主捏的技俩:
1. 2019国度当然科学基金委转变盘算群体科学基金:精神疾病的神经可塑性机制(81821092),2019.01-2021.12,Co-PI
2. 北京脑指标:自闭症和抑郁症应酬与情谊破碎神经环路机制盘算(Z181100001518001),2018.08-2020.08,课题主干。
3. 国度重心研发指标:东说念主工视觉系统中的基础科学问题和变革技艺子课题视神经系统的信息传递(2017YFA0701302),2018.03-2023.02,课题主干。
4. 国度当然科学基金重心海外(地区)互助盘算技俩:低级嗅觉神经元兴隆性:周围神经挫伤与脊髓背侧挫伤后凄冷与开拓的共同调控成分(31720103908),2018.01-2022.12,课题认真东说念主。
5. 国度当然科学基金重心技俩:慢性痛情状下前额叶皮层过火联系环路对痛觉信息编码的调控机制(31530028),2016.01-2020.12,课题认真东说念主。
6. 2016国度当然科学基金委转变盘算群体科学基金:精神疾病的神经可塑性机制(81521063),2016.01-2018.12,Co-PI
7. 国度科技相沿指标:代谢性疾病及神经疾病联系基因的大鼠基因剔除模子设置(2015BAI08B02),2015.4-2017.12,课题主干
8. 国度重心基础盘算发展指标(973):周围神经挫伤后凄冷、嗅觉独特的调控机制与打扰政策(2014CB542204),2014-2018,课题组长
9. 2013国度当然科学基金委要紧盘算指标(培育技俩):前额叶皮质调控痛顾忌和痛负性心境过火交互敏化的微环路及分子采集基础(91332119),2014.01-2016.12,课题认真东说念主
10. 2012国度当然科学基金委转变盘算群体科学基金:精神疾病的神经可塑性机制(81221002),2013.01-2015.12,Co-PI
11. 2011中加(NSFC-CIHR)老年古板症及联系病症互助盘算技俩:功能和遗传盘算决然出的阿尔茨海默病联系激酶在Abeta突触毒性中的作用(81161120497),2012.01-2015.12,课题认真东说念主
12. 训导部转变团队:镇痛和药物成瘾的神经生物学机制,2010-2013,Co-PI
13. 国度隆起后生科学基金:嗅觉系统神经生物学(30925015),2010.01-2013.12,课题认真东说念主
14. 国度当然科学基金重心技俩:慢性痛分子机制探讨——外周伤害性信息整合器TRPV1转录后调控的多档次盘算(30830044),2009.01-2012.12,课题认真东说念主
15. 国度当然科学基金面上技俩:
(1) Cdk5在痛觉敏化中的信号通路盘算(30770703),2008.01-2010.12,课题认真东说念主
(2) 核心神经系统内新式转录因子DREAM 对外周电刺激的频率相应性(30470550),2005.01-2007.12,课题认真东说念主
(3) Cdk5在阿片耐受及成瘾中的作用过火信号转导通路的盘算(30371635),2004.01-2006.12,课题认真东说念主;
16. 国度当然科学基金海外互助相似技俩:
(1) 2012海外生理科学学术大会(31210303062,2012.11-12,课题认真东说念主
(2) 第九届海外凄冷盘算组织谈判会(31110303050),2011.10-12,课题认真东说念主
(3) 第七届东西方海外凄冷会议(31010303031),2010,课题认真东说念主
(4) 中国海外生物活性神经肽会议(30710303033),2007.05,课题认真东说念主
17. 北京市当然科学基金面上技俩:
(1) 新的卵白激酶LIMK在痛觉敏化中的作用及机制盘算(7092061),2009.01-2011.12,课题认真东说念主
麻豆 夏雨荷(2) Cdk5对辣椒素受体功能的出动过火在炎症痛敏中的作用(7072040),2006.12-2009.12,课题认真东说念主
(3) DREAM在100 Hz外周电刺激镇痛中的作用(5052019),2005.01-2007.12,课题认真东说念主
18. 国度重心基础盘算发展指标(973):
(1) 要紧腹黑疾病分子机理和打扰政策的基础盘算(2007CB512100),2007-2011,盘算主干
(2) 脑功能和脑要紧疾病的基础盘算:“突触传递过火调控——受体之间的交谈”(G1999054002),1999.09-2004.09,盘算主干
19. 国度当然科学基金重心技俩:不同类型慢性痛(炎症痛、精神病理痛及癌症痛)的外周和脊髓机制(30330026),2004.01-2007.12,主要完成东说念主
20. 国度当然科学基金后生基金:内吗啡肽在电针镇痛及电针耐受中的作用(39800198),1999.01-2002.12,课题认真东说念主
21. 训导部高校后生教授奖励基金:凄冷机制的盘算(教东说念主司[2001]182号函件),2001.06-2005.06,课题认真东说念主
22. 训导部横向基金“211”II期:PKCmu在阿片耐受及成瘾中的作用过火信号通路的盘算,2003.03-2006,课题认真东说念主
23. 训导部归国东说念主员基金:凄冷过火机制盘算(教外司留[2004]176),2004-2005,课题认真东说念主
学术期刊任职:
现任《生理学报》副主编,《生理科学进展》常务编委。Molecular and Cellular Neuroscience、Fundamental Research、The Open Pain Journal、Experimental Neurology、Neuroscience Bulletin、Neuroprotection、《中国生去世学与分子生物学杂志》和《中国凄冷医学杂志》等杂志编委,《中华医学杂志英文版》同业评议巨匠。
奖励及荣誉称号:
2024年 北京大学课本建设博雅特聘训导
2023年 训导部一流线下课程认真东说念主
2022年 北京高校优质本科课程认真东说念主
2020年 北京高校优秀本科育东说念主团队带头东说念主
2017年 中国女医师协会五洲女子科技奖
2016年 享受国务院政府异常津贴巨匠
2013年 入选训导部长江学者奖励指标特聘训导
2013年 北京市高级训导教学名师奖
2013年 “基础医学阶段本科生转变东说念主才培养体系的构建与现实”获北京市训导教学放胆一等奖
2012年 北京大学十佳教授
2011年 荣获北京市训导工会“训导前锋教书育东说念主先进个东说念主”称号
2011年 荣获2011张香桐神经科学后生科学家
2010年 荣获国度隆起后生科学基金
2010年 荣获宇宙优秀科学科技职责者荣誉称号
2001年 荣获训导部高校优秀后生教授奖
代表性科研论文(CA背负作家):
1. Lyu TJ, Ma J, Zhang XY, Xie GG, Liu C, Du J, Xu YN, Yang DC, Cen C, Wang MY, Lyu NY, Wang YCA, Zhang HQCA. Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice. Mol Psychiatry. 2024 Jan 16. doi: 10.1038/s41380-024-02407-w. Epub ahead of print. PMID: 38228891.
2. Huan-Yu Zheng, Yu-Meng Chen, Yao Xu, Cheng CenCA, Yun WangCA. Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task. J Transl Med. 2023 Dec 10;21(1):897. doi: 10.1186/s12967-023-04778-0.
3. Chen Q, Zhang XY, Wang YP, Fu YJ, Cao F, Xu YN, Kong JG, Tian NX, Xu Y, Wang YCA. Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons. BMC Biol. 2023 Oct 25;21(1):235.
4. Kong JG, Mei Z, Zhang Y, Xu LZ, Zhang JCA, Wang YCA. CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment. Cancer Lett. 2023 Jul 28;567:216265. doi: 10.1016/j.canlet.2023.216265. Epub 2023 Jun 9.PMID: 37302564.
5. Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LICA, Wang YCA. Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons. Adv Sci (Weinh). 2022 Feb 4:e2104317. doi: 10.1002/advs.202104317. Online ahead of print.PMID: 35119221.
6. Wang F, Yin XS, Lu J, Cen CCA and Wang YCA. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory. Sci Signal. 2022 Feb;15(719):eabd0033. doi: 10.1126/scisignal.abd0033. Epub 2022 Feb 1.
7. Liu L, Liu TT, Xie GG, Zhu XQ, Wang YCA. Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL. FASEB J. 2022 Jan;36(1):e22087. doi: 10.1096/fj.202100031RR.PMID: 34888944.
8. Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin SCA, Wang YCA, Min JCA. Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28.
9. Liu H, Su D, Liu L, Chen L, Zhao Y, Chan SO, Zhang W, Wang YCA, Wang JCA. Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1. FASEB J. 2020 Jun 29. doi: 10.1096/fj.202000377R. Online ahead of print.
10. Huang S, Zheng C, Xie G, Song Z, Wang P, Bai Y, Chen D, Zhang Y, Lv P, Liang W, She S, Li Q, Liu Z, Wang Y, Xing GGCA, Wang YCA. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Mol Psychiatry. 2020 Apr 21. doi: 10.1038/s41380-020-0720-x. Online ahead of print.
11. Yin XS, Yang JY, Cao S, Wang YCA. Failure of Placebo Analgesia Model in Rats with Inflammatory Pain. Neurosci Bull. 2020 Feb;36(2):121-133. doi: 10.1007/s12264-019-00420-6. Epub 2019 Aug 21.
12. Li WQ, Luo LD, Hu ZW, Lyu TJ, Cen C, Wang YCA. PLD1 promotes dendritic spine morphogenesis via activating PKD1. Mol Cell Neurosci. 2019 Sep;99:103394. doi: 10.1016/j.mcn.2019.103394. Epub 2019 Jul 26.
13. Liu J, Du J, Wang YCA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal. 2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040.
14. Xu Y, Tian NX, Bai QY, Chen Q, Sun XH, Wang YCA. Gait Assessment of Pain and Analgesics: Comparison of the DigiGaitTM and CatWalkTM Gait Imaging Systems. Neurosci Bull. 2019 Jun;35(3):401-418. doi: 10.1007/s12264-018-00331-y. Epub 2019 Jan 18.
15. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB J. 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789.
16. Guo YP, Zhi YR, Liu TT, Wang Y, Zhang YCA. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats. Front Mol Neurosci. 2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019. PMID: 30740043
17. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang YCA, Yang YCA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9.
18. Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang YCA and Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci. 2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353.
19. Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci. 2018 Jan 3; 38(1):183-199.
20. Luo LD, Li G, Wang YCA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Scientific Reports. 2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2.
21. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA.Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4.
22. Qin R, Cao S, Lyu T, Qi C, Zhang W, Wang YCA.CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043.
23. Zhang C, Lu J, Liu B, Cui QCA, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016 Feb;8(2):272-90.
24. Liu J, Du J, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12.
25. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy. Science Bulletin 2015, 60(9):896-898. (Research Highlight )
26. Wang GQ, Cen C, Cao S, Li C,Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA and Wang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660.
27. Zhang Y, Wang N, Su P, Lu J, Wang YCA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull. 2014, 30(6):1025-35.
28. Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353.
29. Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014, 39(5):1290-301.
30. Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang, YF, Wang YCA and Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 March 26;34(13):4494-508.
31. Li G, Wang YCA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system. Neurosci Bull. 2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.
32. Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang YCA and Wang YCA. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci. 2012 Oct 17;32(42):14709-21.
33. Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DMCA and Wang YCA. PLD1 negatively regulates dendritic branching. J Neurosci. 2012 Jun 6;32 (23):7960-9.
34. Wang KWCA,Wang YCA. Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection? Front Mol Neurosci. (Invited review) 2012 Mar 15;5:39.
35. Chen HJ, Xie WY, Hu F, Zhang Y, Wang J, Wang YCA. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity. Neurosci Bull. April 1, 2012, 28(2): 182-192.
36. Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang YCA. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci. 2010 Jun 2;30(22):7575-86.
37. Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang YCA. Disruption of cdk5- associated phosphorylation of residue threonine-161 of the delta opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J Neurosci. 2009 Mar 18;29(11):3551-64.
38. Yin DM, Huang YH, Zhu YB, Wang YCA. Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J Neurosci. 2008 Aug 27;28(35):8832-43.
39. Zhu HH, Yang YR, Zhang H, Han Y, Li YF, Zhang Y, Yin DM, He QH, Zhao ZQ, Blumberg PM, Han JS, Wang YCA. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain. 2008 Jul 31;137(3):574-88.
40. He Y, Li HL, Xie WY, Yang CZ, Yu AC, Wang YCA. The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte. Glia. 2007 Apr 15;55(6):573-83.
41. Yang YR, He Y, Zhang Y, Li Y, Li YF, Han Y, Zhu HH, Wang YCA. Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain. 2007 Jan; 127(1-2):109-20.
42. Wang YCA, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM. The interaction between PKCmu and vanilloid receptor type 1. J Biol Chem. 2004 Dec 17;279(51):53674-82.
43. Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang YCA. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. Exp Neurol. 2006 Dec;202(2):313-23.
44. Wang YCA, Zhang Y, Wang W, Cao Y, Han JS. Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception. Exp Neurol. 2005 Mar; 192 (1):156-62.
45. Sun RH, Wang HC, Wan Y, Jing Z, Luo F, Han JS,and Wang YCA. Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated. Exp Neurol. 2004 May;187(1):23-9.
46. Wang YCA. The functional regulation of TRPV1 and its role in pain sensitization. Neurochem Res. 2008 Oct;33(10):2008-12. (review)
47. Li Y, Zhang Y, Han JS, Wang YCA. Distinct responses of DREAM to electroacupuncture stimulation with different frequency under physiological and inflammatory conditions in rats. Neurochem Res. 2008 Oct;33(10):2070-7.
48. Zhang Y, Li Y, Yang YR, Zhu HH, Han JS, Wang YCA. Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain. Neurochem Res. 2007, 32(9):1592-9.
49. Lazar J, Braun DC, Toth A, Wang Y, Pearce LV, Pavlyukovets VA, Blumberg PM, Garfield SH, Wincovitch S, Choi HK, Lee J. Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol. 2006 Apr;69(4):1166-73.
50. Zhang Y, Xiang B, Li YM, Wang Y, Wang X, Wang YN, Wu LL, Yu GY. Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland. Biochem Biophys Res Commun. 2006 Jun 23;345(1):467-73.
51. Toth A, Wang Y, Kedei N, Tran R, Pearce LV, Kang SU, Jin MK, Choi HK, Lee J, Blumberg PM. Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci. 2005 May 6; 76(25):2921-32.
52. Lee J, Jin MK, Kang SU, Kim SY, Lee J, Shin M, Hwang J, Cho S, Choi YS, Choi HK, Kim SE, Suh YG, Lee YS, Kim YH, Ha HJ, Toth A, Pearce LV, Tran R, Szabo T, Welter JD, Lundberg DJ, Wang Y, Lazar J, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4143-50.
53. Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, Wang Y, Szabo T, Pearce LV, Lundberg DJ, Toth A, Pavlyukovets VA, Morgan MA, Blumberg PM. Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4136-42.
54. Lee J, Kang SU, Lim JO, Choi HK, Jin MK, Toth A, Pearce LV, Tran R, Wang Y, Szabo T, Blumberg PM. N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’. Bioorg Med Chem. 2004 Jan 15;12(2):371-85.
55. Lee J, Kim SY, Lee J, Kang M, Kil MJ, Choi HK, Jin MK,Wang Y, Toth A, Pearce LV, Lundberg DJ, Tran R, Blumberg PM. Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism. Bioorg Med Chem. 2004 Jul 1;12(13):3411-20.
56. Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM. Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. Bioorg Med Chem Lett. 2004 May 3;14(9):2291-7.
57. Tang XQ, Wang Y, Huang ZH, Han JS, Wan Y. Adenovirus-mediated GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury. NeuroReport. 2004 Mar 1;15(3):425-9.
58. Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. High affinity partial agonists of vanilloid receptor. Mol Pharmacol. 2003 Aug;64(2):325-33.
59. Wang Y, Szabo T, Welter JD, Toth A, Tran R, Lee J, Kang SU, Suh YG, Blumberg PM, Lee J. High affinity antagonists of the vanilloid receptor. Mol Pharmacol. 2002 Oct;62(4):947-56.
60. Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS. Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neuroscience. 2003;117(3):503-12.
61. Tóth A, Kedei N, Wang Y, Blumberg PM. Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat. Life Sci. 2003 Jun 13;73(4):487-98.
62. Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonists and Partial Antagonists of the Vanilloid Receptor. J Med Chem. 2003 Jul 3;46(14):3116-26.
63. Tóth A, Kedei N, Szabó T, Wang Y, Blumberg PM. Thapsigargin binds to and inhibits the cloned vanilloid receptor-1. Biochem Biophys Res Commun . 2002 May 3;293(2):777-82.
64. Huang C, Wang Y, Han JS, Wan Y. Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement. Brain Res. 2002 Jul 26;945(1):20-5.
65. Wang Y, Wang XM, Han JS. Discrimination between peptide and non-peptide opioid agonists on the transcription of opioid receptors in two cell lines. Life Sci . 2001 May 4;68(24):2731-40.
66. Chen ZW, Yang K,Wang YCA, Han JS. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells. NeuroReport. 2001 Mar 26;12(4):845-9.
67. Chen ZW, Yang K,Wang YCA, Han JS. The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans. Neurosci Lett. 2001 Feb 9;298(3):199-202.
68. Sun R, Wang YCA, Zhao CS, Chang JK, Han JS. Changes in Brain content of nocicepin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain. Neurosci Lett. 2001 Sep 21;311(1):13-6.
69. Tang XQ, Wang Y, Han JS, Wan Y. Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury. Neuroreport. 2001 Oct 8;12(14):3073-6.
70. Sun RQ, Zhao CS, Wang HJ, Jing Z, Wang W, Yang K,Wang Y, Chang JK, Han JS. Nocistatin, a peptide reversing acute and chronic morphine tolerance. Neuroreport. 2001 Jun 13;12(8):1789-92.
71. Huang C, Wang YCA, Chang JK, Han JS. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation. Neurosci Lett . 2000 Nov 24;294(3):159-62.
72. Wang Y, Huang C, Cao Y, Han JS. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in rat. Life Sci . 2000 Jun 8;67(3):261-7.
73. Fang M, Wang Y, Liu HX, Liu XS, Han JS. Decreased GDNF expression in dorsal spinal cord of unilateral arthritic rat. NeuroReport. 2000 Mar 20;11(4):737-41.
74. Zhao CS, Li BS, Zhao GY, Liu HX, Luo F, Wang Y, Tian JH, Chang JK, Han JS. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia .NeuroReport. 1999 Feb 5;10(2):297-9.
75. Han Z, Jiang YH, Wan Y, Wang Y, Chang JK, Han JS. Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat. Neurosci Lett. 1999 Oct 22;274(2):75-8.
主编,主译及参编订述:
1.《神经科学》(第四版)韩济生 主编,北京大学医学出书社,北京,2022年11月,ISBN:978-7-5659-2735-6。王韵,第四篇第9章,神经肽II:阿片肽过火受体,p595-614。
2.《神经与精神疾病》(第二版)(国度卫生健康委员会“十四五”测度课本及宇宙高级学校器官系统整合课本). 闫剑群等主编。东说念主民卫生出书社,北京,2021年10月,ISBN 978-7-117-31507-4. 王韵,第三章,神经生理。
3. 《疾病学基础》. 副主编,第二章疾病的神经内分泌机制选取十六章神经退行性疾病(国度卫生健康委员会十三五测度课本,专科医师核心才气提高诱掖丛书,供专科学位盘算生及专科医师用). 东说念主民卫生出书社,北京,2021年11月初版,ISBN:978-7-117-31569-2。
4. “以器官系统为中心”翻译课本,神经系统—基础与临床(第二版),主译,北京大学医学出书社,北京,2019年7月初版,ISBN:978-7-5659-2002-8。
5. Y Xu and Wang Y*. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors. In: Victor R. Preedy, editors, The Neuroscience of Cocaine. Academic Press, 2017, pp. 183-194. ISBN: 978-0-12-803750-8. Copyright. 2017 Elsevier Inc. Academic Press.
6. 《凄冷学》(初版),韩济生主编,北京大学医学出书社,北京,2012年2月第1版,ISBN:978-7-5659-0198-0。王韵,第9章,阿片及阿片受体系统,p78-89。国度“十一五”重心史籍。
7. 《神经生物学》(初版),于龙川主编,北京大学出书社,北京,2012年8月第1版,ISBN:978-7-301-21113-7。张瑛,王韵,第3篇第12章,神经系统的嗅觉功能,p287-329。适用于概括性大学本科生和盘算生课本。
8. 《神经科学》第三版,韩济生主编,北京大学医学出书社,北京,2009年1月第3版,ISBN:978-7-81116-605-7。王韵,第24章,神经肽II:阿片肽过火受体,p438-455。
9. 《镇痛药盘算技艺学》(初版),洪庚辛主编,东说念主民卫生出书社,北京,2009年4月第1版,ISBN:978-7-117-11072-3。王韵,第3章,神经递质、调质与凄冷,p37-49。
发明专利:
1. 王韵,张瑛,苏萍,朱彦兵,韩涛。按捺兴隆性毒性挫伤的多肽过火应用,中国发明专利,专利号ZL 2009 1 088565.9,肯求日:2009.07.03;授权日:2012.03.21。
2. 王韵,杨艳蕊,邢宝明,杜军霞,张瑛。一种防护和/或调理凄冷的多肽过火应用,中国发明专利,专利号ZL2012 1 0293185.0,肯求日:2012.08.16;授权日:2014.02.19。
3. 王韵,苏萍,康凯,王宁。按捺可卡因诱发的高诱导活性的多肽过火应用,中国发明专利,专利号ZL2011 1 0235076.9,肯求日:2011.08.16;授权日:2013.03.27。
4. 王韵,李逸,陈海靖,胡芳,杜怡娟。一种具有镇痛作用的可穿膜多肽,中国发明专利,专利号ZL2013 1 0399841.X,肯求日:2013.09.05;授权日:2015.04.29。
5, 王韵,岑程,李文琪,李刚,罗丽达。一种具有提高学习顾忌才气的多肽TAT-836-871过火应用,中国发明专利,专利号ZL 2015 1 0341194.6,肯求日2015.6.18,授权日2018.11.13。
6. 王韵,岑程,李文琪,李刚,罗丽达。一种具有提高学习顾忌才气的多肽TAT-N-cad S3过火应用,中国发明专利,专利号ZL 2015 1 0342161.3,肯求日2015.6.18,授权日2018.12.25。
7. 王韵,田纳西,徐煜,岑程,王国强,陈琪,王昱普。一种辣椒平水凝胶过火在开拓周围神经挫伤和收复诱导功能中的应用,肯求日2019.12.9,专利肯求号201911249380.1
8. 王韵,孔金阁,梅竹,张君。一种用于防护和/或调理胶质瘤变成的产物,肯求日2021.10.29,专利肯求号202111263968.X 。
9.王韵, 陈琪,傅韵洁,王昱普,张希寅。专利称号:PACAP38 在缓解精神病感性凄冷和促进神经再生中的应用,肯求日2022.12.13,专利肯求号:202211593555.2。
教学文章:(*通信作家)
1. 蒲丹,吴立玲,沈惠麒,张燕,王嘉东,王韵*,基础医学专科本科生科研想维锻真金不怕火课程教学效果分析,中华医学训导杂志,2022, 42 : 146-150.
2. 蒲丹,张燕,王韵*,以才气为中心的考察评估鼓吹后疫情期间基础医学在线教学的校正与发展,生理学报,2020, 72 : 737-742.
3. 蒲丹,张嵘,潘燕,吴立玲,张燕,王韵*,“基于问题学习”在线教学决策的实行效果. 中华医学训导杂志,2021, 41:139-142.
4. 侯建林,王韵,蒲丹,张燕,王颖,崔爽,郭立,柯杨*,新容貌下对我国临床医学训导的反想,中华医学训导杂志,2021, 41: 197-200.
5. 蒲丹,倪菊华,吴立玲,王韵*,应酬样式通过学习疲顿影响学习收获的探究,中国健康激情学杂志,2020, 28: 604-607.
6. 张瑛,孔金阁,王韵*,神经生物学情境化命题技巧过火效果评价,中国医学训导杂志,2020, 40: 832-836.
7. Pu D, Ni J, Song D, Zhang W, Wang Y, Wu L, Wang X, Wang Y*. Influence of critical thinking disposition on the learning efficiency of problem-based learning in undergraduate medical students. BMC Med Educ. 2019 Jan 3;19(1):1. doi: 10.1186/s12909-018-1418-5. PubMed PMID: 30606170.
8. 蒲丹,倪菊华,吴立玲,王韵*,“基于问题的学习”中学习疲顿风物过火原因分析,中华医学训导杂志,2018,38(6):815-819
9. 蒲丹,吴立玲,王韵*,基于问题学习教学对医学生批判性想维影响的盘算,中华医学训导杂志,2018,38(5):705-708
10. 蒲丹,吴立玲,宋德懋,曾辉,时月芹,王宪,王韵*. “基于问题的学习”中基础学科与临床学科纠合教导的教学效果观望,中国医学训导技艺,2016,30(5):597-600.
11. 蒲丹,倪菊华,宋德懋,吴立玲,王宪,王韵*,低年事医学生批判性想维近况及与基础医学课程收获的联系性,基础医学与临床,2015,35(11):1572-1575
12. 蒲丹,李彤,彭宜红,何晓燕,吴立玲,王宪,管又飞,王韵*. 基础常识与PBL学习经过对医学生才气提高的不同影响,基础医学与临床,2014,34(11):1590-1593
13. 蒲丹,倪菊华,任雅丽,王韵,吴立玲,王宪,管又飞*,医学生对不同职称和专科配景PBL教授教学效果评估的盘算,基础医学与临床,2013,33(12):1650-1653;
14. 张燕,蒲丹,吴立玲,王韵,宋德懋,倪菊华,王月丹,张卫光,李学军,王宪,管又飞*. 基础医学训导阶段本科生转变东说念主才培养体系的构建与现实。中华医学训导杂志,2013,33(1): 29-32
15. 张瑛,刘风雨,于常海,万有,崔彩莲找色妹妹,韩济生,蔡景一,王韵*. 神经生物学凄冷专题以问题为基础学习与以讲课为基础学习相迷惑的教学探索。中华医学训导杂志, 2009,29(5): 90-92.